Pharmacology
Biology / pharmacology.yaml 5 records
2 sections
pharmacokinetics 3 interactions 2
pharmacokinetics
| Drug | Bioavailability | Half Life | Protein Binding | Metabolism | Excretion |
|---|---|---|---|---|---|
| Aspirin | 50-68% | 0.25h (parent), 3-6h (metabolite) | 80-90% | Liver (hydrolysis) | Renal |
| Ibuprofen | 80-100% | 1.8-2h | 90-99% | Liver (CYP2C9) | Renal |
| Metformin | 50-60% | 6.2h | Negligible | None | Renal (unchanged) |
interactions
| Drug1 | Drug2 | Mechanism | Severity | Description |
|---|---|---|---|---|
| Warfarin | Aspirin | Pharmacodynamic synergism (antiplatelet effect) | Major | Increased risk of bleeding. |
| Simvastatin | Grapefruit Juice | CYP3A4 inhibition | Moderate | Increased serum concentration of simvastatin. |